Antigen Seeding Technology (AST) is a Potent and Complimentary Addition to Company’s Engineered Toxin Bodies (ETB) Technology
AUSTIN, Texas, Nov. 09, 2018 (GLOBE NEWSWIRE) — Molecular Templates, Inc., (Nasdaq: MTEM), a medical-degree oncology company targeted on the discovery and improvement of the organisation’s proprietary engineered toxin our bodies (ETBs), which can be differentiated, centered, biologic therapeutics for most cancers, introduced the presentation today of a poster on its PD-L1 ETB with Antigen Seeding Technology (AST) at the continuing Society for Immunotherapy of Cancer’s (SITC) 33rd Annual Meeting, currently taking region in Washington D.C.
Antigen Seeding Technology represents a singular immune-oncology technique leveraging the novel mechanism of action of Molecular Templates’ ETB era. ETBs engineered with Antigen Seeding Technology are able to hand over viral antigens as a payload inside the target tumor, resulting within the antigens being supplied at the cellular surface of the tumor cells in complicated with MHC-1. ETB therapeutics incorporating antigen seeding are designed to work through twin mechanisms of movement through redirecting a high avidity, pre-present antigen-unique cytotoxic T cell (CTL) response to the tumor at the same time as at the same inducing cell demise thru the enzymatic and everlasting destruction of ribosomes. Coupling awesome mechanisms of tumor cellular killing into one ETB molecule offers the ability to growth target penetrance, increase a extended immune response, and overcome tumor resistance.
The poster, titled “Identification and Functional Profiling of PD-L1 Targeted Engineered Toxin Bodies for Antigen Seeding Technology (AST) and Redirection of T cellular Response to Tumors” summarizes a series of preclinical experiments conducted by Molecular Templates to create PD-L1 targeted ETBs which have antigen seeding residences and to investigate the mechanisms with the aid of which they are able to kill cancer cells.
“Antigen Seeding Technology represents a novel method to immune-oncology that can be lively in sufferers where widespread immune-oncology techniques had been exhausted,” said Eric Poma, Ph.D., Molecular Templates’ Chief Executive, and Scientific Officer. “We are currently accomplishing in vivo research with PD-L1 centered ETBs that have AST capability. Our plan is to report an IND and enter the hospital with our first PD-L1 ETB candidate using AST in 2019.”
Poster Presentation Details:
The poster (#P9) will be to be had to view in Hall E of the Walter E. Johnson Convention Center these days, Friday, Nov. 9 from eight a.M. – 8 p.M. And Saturday, Nov. 10 from 8 a.M. – 8:30 p.M. (all instances are E.T.)
The poster may be observed under “Clinical and Scientific Presentations” at http://ir.Mtem.Com/events-and-displays/displays.
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